Neuroprotective effect of liposome-encapsulated hemoglobin as an artificial oxygen carrier
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چکیده
منابع مشابه
Use of Liposome Encapsulated Hemoglobin (leh) as an Oxygen Carrier to Cultured Cells
Oxygen transport is the most constraining parameter to engineer three-dimensional (3 D) tissues in vitro. The concentration of oxygen dissolved in the culture medium according to the Henry's law is very low (about 2×10 mol/mL under 21%-O2 containing air), and it is not likely to satisfy the metabolic demand of a high cell density tissue such as liver (e.g., 2.5 ×10 parenchymal cells/mL-in vivo ...
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The hemoglobin vesicle (HbV) is an artificial oxygen carrier that encapsulates a concentrated Hb solution in lipid vesicles (liposomes). The pharmacokinetic properties of HbV were investigated in mice and rats. With use of HbV in which the internal Hb was labeled with (125)I ((125)I-HbV) and cell-free (125)I-Hb, it was found that encapsulation of Hb increased the half-life by 30 times, accompan...
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Hemoglobin vesicles (HbVs) are oxygen carriers consisting of Hb molecules and liposome in which human hemoglobin (Hb) molecules are encapsulated. Investigations of HbV biocompatibility have shown that HbVs have no significant effect on either the quality or quantity of blood components such as RBC, WBC, platelets, complements, or coagulation factors, reflecting its excellent biocompatibility. H...
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To enhance the curcumin absorption by oral administration, liposome-encapsulated curcumin (LEC) was prepared from commercially available lecithins (SLP-WHITE and SLP-PC70) and examined for its interfacial and biochemical properties. A LEC prepared from 5 wt % of SLP-PC70 and 2.5 wt % of curcumin gave a good dispersibility with 68.0% encapsulation efficiency for curcumin, while those from SLP-WH...
متن کاملLiposome-encapsulated hemoglobin ameliorates ischemic stroke in nonhuman primates: an acute study.
An artificial oxygen carrier, liposome-encapsulated hemoglobin (LEH), protective in a rodent stroke model, was quantitatively evaluated in monkeys. Serial positron emission tomography studies using the steady-state (15)O-gas inhalation method were performed to quantify O(2) metabolism, which was compared based on the infarction extent and immunohistochemical evaluation in 19 monkeys undergoing ...
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ژورنال
عنوان ژورنال: Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism)
سال: 2014
ISSN: 0915-9401,2188-7519
DOI: 10.16977/cbfm.25.2_51